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SUMMARY:Rapid 3D Bioprinting for Precision Tissue Engineering - Prof Shaoc
 hen Chen\, Chair of NanoEngineering Department\, University of California
DTSTART:20201120T160000Z
DTEND:20201120T170000Z
UID:TALK151753@talks.cam.ac.uk
CONTACT:Hilde Hambro
DESCRIPTION:In this talk\, I will present our laboratory’s recent resear
 ch efforts in developing rapid 3D bioprinting methods to create 3D tissue 
 constructs using a variety of biomaterials and cells. These 3D printed sca
 ffolds are functionalized with precise control of micro-architecture\, mec
 hanical (e.g. stiffness)\, chemical\, and biological properties [1]. Such 
 functional scaffolds allow us to investigate cell-microenvironment interac
 tions at nano- and micro-scales in response to integrated mechanical and c
 hemical stimuli. From these fundamental studies we have been creating both
  in vitro and in vivo precision tissues for tissue regeneration\, disease 
 modeling\, and drug discovery [2\,3]. Examples including 3D bioprinted liv
 er and heart models will be discussed. I will also showcase 3D printed bio
 mimetic scaffolds for treating spinal cord injury. Throughout the presenta
 tion\, I will discuss mechanical engineer’s perspectives in terms of des
 ign innovation\, biomaterials\, mechanics\, and scalable manufacturing. \n
 1.	Yu C\, Ma X\, Zhu W\, Wang P\, Miller K\, Stupin J\, Koroleva-Maharajh 
 A\, Hairadedian A\, Chen S\, “Scanningless and continuous 3D bioprinting
  of human tissues with decellularized extracellular matrix”\, Biomateria
 ls\, Vol. 194\, pp 1-13\, 2019\n2.	Ma X\, Qu X\, Zhu W\, Li Y\, Yuan S\, Z
 hang H\, Liu J\, Wang P\, Lai C\, Zanella F\, Feng G\, Sheikh F\, Chien S\
 , Chen S\, “A Deterministically Patterned Biomimetic Human iPSC-derived 
 Hepatic Model via Rapid 3D Bioprinting”\, Proceedings of the National Ac
 ademy of Sciences (PNAS)\, 2016\, Vol. 113 (no. 8)\, pp. 2206-2211\, 2016.
  \n3.	Koffler J\, Zhu W\, Qu X\, Platoshyn O\, Dulin J\, Brock J\, Graham 
 L\, Lu P\, Sakamoto J\, Marsala M\, Chen S\, Tuszynski M\, “Biomimetic 3
 D Printed Scaffolds for Spinal Cord Injury”\, Nature Medicine\, Vol.25\,
  pp.263-269\, 2019.  \n
LOCATION:zoom 853 4440 7455 - for password email yc512@cam.ac.uk
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