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CATEGORIES:MRC LMB Seminar Series
SUMMARY:Study virus assembly and host interactions in vitr
 o and in cells by cryoEM and cryoET  - Peijun Zhan
 g\, Professor of Structural Biology and Wellcome T
 rust Investigator\, University of Oxford 
DTSTART;TZID=Europe/London:20200908T110000
DTEND;TZID=Europe/London:20200908T120000
UID:TALK150253AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/150253
DESCRIPTION:With cryoEM\, structures of purified proteins and 
 protein complexes can be routinely determined to n
 ear-atomic resolution using single particle analys
 is (SPA) method. Structures of macromolecular comp
 lexes that are intrinsically flexible and non-homo
 geneous\, and often function in higher-order assem
 blies that are difficult to purify\, have recently
  been analyzed to near near-atomic resolution usin
 g cryo-electron tomography and sub-tomogram averag
 ing (cryoET STA). The study of these complexes and
  assemblies in cells using cryoET STA\, coupled wi
 th cryoFIB and correlative imaging\, opens a new f
 rontier in structural cell biology. I will present
  our recent studies on HIV-1 capsid and its intera
 ction with host factor cyclophilin A\, cellular as
 sembly of human reovirus and infection of SARS-Cov
 -2\, to illustrate the power of integrated multisc
 ale imaging from atoms to cells by cryo-electron m
 icroscopy. 
LOCATION:Webinar via Zoom - https://zoom.us/j/97493748184?p
 wd=Z1dZM2pxUk16QytPeU5NVWZ3bnZmdz09 Meeting ID: 97
 4 9374 8184 Passcode: 404662
CONTACT:Scientific Meetings Co-ordinator
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