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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Session 2 - PLENARY TALK by Ruth Bowness - Univers
ity of St. Andrews - Modelling within-host tubercu
losis infection using a hybrid multiscale individu
al-based model -
DTSTART;TZID=Europe/London:20200708T120000
DTEND;TZID=Europe/London:20200708T130000
UID:TALK149845AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/149845
DESCRIPTION:Tuberculosis (TB) i
s an infectious disease caused by Mycobacterium tu
berculosis. Despite significant recent advances\,
TB is the biggest infectious killer globally - som
eone dies from the disease every 18 seconds. I wil
l describe a hybrid multiscale individual-based mo
del that has been developed to study disease progr
ession and treatment in the human lung. The model
contains discrete agents which model the spatio-te
mporal interactions (migration\, binding\, killing
etc.) of bacteria and immune cells. Chemokine and
oxygen dynamics are also included\, as well as Ph
armacokinetic/Pharmacodynamic models\, which are i
ncorporated into the model via PDEs. In this work\
, I explore concepts of relapse and latent TB dise
ase\, and their effect on treatment outcome.
a>
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:INI IT
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