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SUMMARY:Intracellular trafficking of mitochondria and neuronal ageing - Al
 essio Vagnoni\, IoPPN\, King's College London
DTSTART:20191113T173000Z
DTEND:20191113T193000Z
UID:TALK133903@talks.cam.ac.uk
CONTACT:Alexis
DESCRIPTION:Proper distribution of mitochondria in axons and dendrites is 
 crucial for many neuronal functions. Work in cell culture and intact organ
 isms suggests that early decline of mitochondrial axonal transport is a ha
 llmark of ageing and neurodegeneration. Although reduced transport contrib
 utes to the broader decline of neuronal homeostasis that occurs during age
 ing\, it is still unclear how decline in motility mechanistically affects 
 ageing and neurodegenerative phenotypes. Mounting evidence supports the id
 ea that mitochondrial transport and function are mechanistically linked. T
 hus\, halting motility would likely be followed by a rapid functional resp
 onse. However\, this hypothesis has not been extensively tested\, partly d
 ue to the lack of suitable systems to inhibit the transport of mitochondri
 a with high spatiotemporal precision. Despite the growing array of optogen
 etic tools\, ways to interfere with the mitochondrial transport machinery 
 at the endogenous level in vivo are currently scarce.\nDuring my talk I wi
 ll discuss our current approaches to this complex problem\, including intr
 oducing new tools that we are developing in order to interfere with mitoch
 ondrial motility and function with high spatiotemporal precision.
LOCATION:Gurdon Institute Tea Room
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