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CATEGORIES:Darwin College Science Seminars
SUMMARY:Investigating human blood development at the singl
 e-cell level - Anna Maria Ranzoni - Wellcome - MRC
  Cambridge Stem Cell Institute/Wellcome Trust Sang
 er Institute
DTSTART;TZID=Europe/London:20191205T131000
DTEND;TZID=Europe/London:20191205T140000
UID:TALK132607AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/132607
DESCRIPTION:Blood production during foetal development involve
 s separate waves of \nmigration of rare stem cells
  among different organs\, including aorta\, \nlive
 r and bones. It is still unclear how human foetal 
 blood stem cells \narise\, expand and differentiat
 e in the more than ten cell types that \ncarry out
  vital body functions such as carrying oxygen\, cl
 otting and \nfighting infections. In my research\,
  I utilise a variety of \ntechnologies\, including
  single-cell RNA sequencing\, whole genome \nseque
 ncing and cell-culture assays\, to characterise fo
 etal blood \nprogenitors and to understand how ste
 m cells colonise the different \norgans during dev
 elopment. Uncovering the dynamics of blood product
 ion \nin foetal development has both biological an
 d translational \nimplications. Foetal stem cells 
 have a higher regenerative potential \nthan their 
 adult counterparts and studying them could provide
  important \ninsights on how we can mimic these pr
 operties in the production of blood \nstem cells e
 x-vivo for regenerative medicine purposes.
LOCATION:The Richard King Room\, Darwin College
CONTACT:David Gershlick
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