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SUMMARY:Mitochondria and Cancer: Metabolites and Beyond - Christian Frezza
 \, University of Cambridge
DTSTART:20200214T160000Z
DTEND:20200214T170000Z
UID:TALK132556@talks.cam.ac.uk
CONTACT:Diana Fusco
DESCRIPTION:The role of mitochondrial dysfunction in cancer has been debat
 ed for over a century. Recent bioinformatic data analyses revealed that mi
 tochondrial genes are suppressed in cancer with poor clinical outcome. Fur
 thermore\, the fact that mutations of core metabolic enzymes in the mitoch
 ondria such as Fumarate Hydratase (FH) cause renal cancer strongly indicat
 es that mitochondrial dysfunction can drive cancer. Today\, I will provide
  an overview of our recent findings about the molecular mechanisms through
  which mitochondrial dysfunction caused by the loss of FH can drive transf
 ormation and shape cancer progression. 
LOCATION:Ryle Seminar (Rutherford 930)
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