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CATEGORIES:Babraham Seminar
SUMMARY:“iPS Proteomes in Health and Disease&quot\; - Prof
 . Angus Lamond\; School of Life Sciences\, Univers
 ity of Dundee
DTSTART;TZID=Europe/London:20191111T120000
DTEND;TZID=Europe/London:20191111T130000
UID:TALK130270AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/130270
DESCRIPTION:Deep mining of proteomes\, using mass spectrometry
  (MS) based proteomics technology\, can provide in
 valuable insights\, at a systems level\, into both
  physiological responses in healthy cells and mech
 anisms causing disease phenotypes. This allows unb
 iased\, global\, quantitative measurements linking
  cellular phenotypes with changes in protein dynam
 ics in both healthy and diseased cells. A major ch
 allenge that emerges from this ability to generate
  very large sets of proteomics and parallel ‘poly-
 omics’ data is how to manage\, analyse and integra
 te the huge resulting volumes of complex informati
 on. I will describe our progress in a large-scale\
 , poly-omics project where we have used quantitati
 ve proteomics to analyse many different human indu
 ced pluripotent stem cell lines (iPSCs)\, derived 
 from both healthy donors and patient cohorts with 
 inherited genetic disorders. This project highligh
 ts some of the technical and analytical challenges
  inherent in performing proteomic analyses at this
  scale. I will also describe user-friendly\, compu
 tational tools we have built for the effective man
 agement and sharing of these large\, multidimensio
 nal data sets (see\; www.peptracker.com/epd). Our 
 results show that disease causing mutations result
  in alterations in the proteomes of iPSC lines tha
 t reflect phenotypic defects observed in different
 iated adult tissue in patients.
LOCATION:Babraham - The Cambridge Building - Kings Hedges R
 oom
CONTACT:Bobbie Claxton
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