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CATEGORIES:Cambridge Infectious Diseases
SUMMARY:Melville Seminar : Broad-spectrum antiviral materi
 als - Dr Samuel Jones\, Dame Kathleen Ollerenshaw 
 Fellow  University of Manchester
DTSTART;TZID=Europe/London:20190920T140000
DTEND;TZID=Europe/London:20190920T150000
UID:TALK129907AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/129907
DESCRIPTION:Antivirals currently only exist for 9 out of the 2
 19 known human viral diseases\, are virus-specific
  and lose efficacy upon viral mutation. A broad-sp
 ectrum antiviral\, the equivalent of broad-spectru
 m antibiotics\, is needed\, especially in the figh
 t against emerging viral outbreaks. Recent work ha
 s shown that highly sulfonated nanomaterials act i
 n such a broad-spectrum antiviral manner due to mu
 ltivalent interactions. This led to us producing t
 he first ever fully-organic (sugar based) broad-sp
 ectrum virucidal antiviral and most recently synth
 etic polymer-based materials that also show broad-
 spectrum antiviral properties. These materials wor
 k via a newly proposed disruptive binding approach
  that effectively 'pops' the viral capsids. Eviden
 ce is provided by electron microscopy\, molecular 
 dynamic simulations and in-vitro\, ex-vivo and in-
 vivo assays. My talk will introduce the importance
  of developing new antivirals\, highlight the adva
 ntages to an extracellular virucidal approach and 
 give examples of different materials that we have 
 shown can be produced with such antiviral properti
 es. 
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
CONTACT:Allyson Walsh
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