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SUMMARY:Conceptual and methodological advances in laminar fMRI - David Nor
 ris\, Donders Institute for Brain\, Cognition and Behaviour\, Radboud Univ
 ersity
DTSTART:20200309T123000Z
DTEND:20200309T133000Z
UID:TALK129580@talks.cam.ac.uk
CONTACT:Johan Carlin
DESCRIPTION:This talk will examine recent progress in laminar fMRI made by
  our group and others. We will categorise laminar experiments in terms of 
 a framework that distinguishes three main types of response: (I) the respo
 nse of a cortical region to sensory afferences\; (II) the response of a fu
 nctional sub- unit such as a layer\; (III) the response of a functional su
 b- unit associated with its ongoing state\, or (feedback) interactions wit
 h another region\, that can generally only be revealed with the help of a 
 contemporaneously recorded signal. Type III responses explain how afferent
  sensory activity is modulated by internal neuronal states\, and may offer
  the most information to neuroscience\, but are also the most challenging 
 to measure. \n\nCurrently\, the two most popular acquisition techniques fo
 r laminar fMRI are gradient-echo BOLD and CBV as measured with VASO. Spin-
 echo BOLD is also a viable alternative. These three methods make different
  trade-offs in terms of sensitivity\, spatial specificity\, and volume cov
 erage. I hypothesise that the specificity of these techniques depends on t
 he type of response being measured\, and in particular\, that for gradient
 -echo BOLD it is considerably improved when measuring Type III responses. 
 I will support this claim on the basis of recently published and ongoing w
 ork from our group.
LOCATION:Lecture Theatre\, MRC Cognition and Brain Sciences Unit\, 15 Chau
 cer Road\, Cambridge
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