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SUMMARY:Kid-mediated anaphase chromosome compaction ensures proper nuclear
  envelope formation - Dr. Miho Ohsugi\,  Institute of Medical Science\, Th
 e University of Tokyo
DTSTART:20080603T150000Z
DTEND:20080603T160000Z
UID:TALK12377@talks.cam.ac.uk
CONTACT:Masanori Mishima
DESCRIPTION:Toward the end of mitosis\, neighboring chromosomes gather clo
 sely to form a compact cluster before nuclear envelope reassembly begins. 
 This is important for reassembling the nuclear envelope around the entire 
 chromosome mass\, but not individual chromosomes.\n By analyzing mice and 
 cultured cells lacking expression of chromokinesin Kid/kinesin-10\, we sho
 wed that Kid localizes to the boundaries of anaphase and telophase chromos
 omes and helps to hold individual chromosomes together to form a compact c
 hromosome mass at telophase. In mice\, loss of the Kid-mediated anaphase c
 hromosome compaction often causes the formation of multinucleated cells\, 
 specifically at oocyte meiosis II and the first couple of mitoses\, leadin
 g to embryonic death. In contrast\, neither male meiosis nor somatic mitos
 is after the morula-stage is fatally affected by Kid-deficiency. These dat
 a suggest that Kid-mediated anaphase chromosome compaction is specifically
  essential for mammalian early-stage embryos\, which are under the strong 
 influence of the ooplasm\, to encapsulate chromosomes into one nucleus.\n\
 nCell 132: 771-782 (2008)\n\n
LOCATION:Gurdon Institute Tea Room
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