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SUMMARY:Melville Lectures 2019 - "Luminescent complexes: assemblies\, sens
 ing\, towards artificial virus" - Professor Luisa De Cola
DTSTART:20190207T140000Z
DTEND:20190207T150000Z
UID:TALK120094@talks.cam.ac.uk
CONTACT:Ishita Ratna De
DESCRIPTION:Luminescent molecules that can undergo self-assembly are of gr
 eat interest for the development of new materials\, sensors\, biolabels…
 . The talk will illustrate some of the recent results on soft structures b
 ased on metal complexes able to aggregate in fibers\, gels and soft mechan
 ochromic materials[1]. The emission of the compounds can be tuned by an ap
 propriate choice of the coordinated ligands as well as of their aggregatio
 n in different structures. The formation of soft assemblies allows the tun
 ing of the emission color\, by pressure and temperature leading to a new c
 lass of materials possessing reversible properties. The monitoring of the 
 different emission properties\, used as fingerprint for each of the assemb
 led species\, allowed an unprecedented real-time visualization of the evol
 ving self-assemblies[2]. The assemblies can be employed as very sensistive
  labels for the detection of toxins and drugs[3]. Indeed even though sensi
 ng based on fluorescent and luminescent probes are commonly used\, the use
  of aggregates in water allows to distinguish between analytes possessing 
 very similar electronic properties. Sensing can also be done using electro
 chemiluminescence\, ECL. We have recently achieved the first example of ag
 gregation induced ECL showing that assemblies in solution and in the solid
  state (deposited on the electrode) can generate bright emission[4]. Final
 ly I wish to close my talk showing novel capsules that can be realized usi
 ng a unique approach to template virus proteins to reconstruct virus-like 
 particles. We use supramolecular structures in water solutions\, that can 
 act as templates of viruses capsid proteins. The assemblies can have diffe
 rent morphologies and extremely high emission of which the color depends o
 n the assembly. Interestingly we are able to change the size and shape of 
 the particles even though we use the same natural proteins[5].\n\nReferenc
 es\n[1] C. A. Strassert\, L. De Cola et al. Angew. Chem. Int. Ed.\, 2011\,
  50\, 946\; M. Mauro\, L. De Cola et al. Chem. Commun. 2014\, 50\, 7269\,
  \n[2] A. Aliprandi\, M. Mauro\, L. De Cola Nature Chemistry \, 2016\, 8\,
  10-15\n[3] S. Sinn\, L. De Cola et al. Chem. Eu. J.\, 2017\, 23\, 1965-1
 971.\n[4]  S. Carrara\, A. Aliprandi\, C. Hogan\, L. De Cola J. Am. Chem. 
 Soc. 2017\, 39\, 14605–14610.\n[5] S. Sinn\, L . De Cola et al. J. Am. 
 Chem. Soc. 2018\, 140\, 2355-2362.\n
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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