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SUMMARY:Constitutive heterochromatin regulation of genome organisation and
  stability in mouse embryonic stem cells - Dr Clara Novo\, Babraham Instit
 ute
DTSTART:20190205T123000Z
DTEND:20190205T133000Z
UID:TALK119443@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Constitutive heterochromatin domains (CH) are major contributo
 rs to the organization and stability of the genome but the underlying mole
 cular mechanisms remain unknown. Furthermore\, the nuclear distribution of
  CH undergoes massive reorganization during early embryogenesis\; terminal
  differentiation of muscle and brain cells and in tumorigenesis. The estab
 lishment and organization of CH loci relies largely on their chromatin ide
 ntity rather than the underlying DNA sequence. \nPluripotent embryonic ste
 m cells (ESCs) have an unusually permissive and hyper-transcribed chromati
 n\, even at typically repressed CH loci\, like telomeres and pericentromer
 es. Furthermore\, the clustering of CH into remarkably few and large chrom
 ocentres (cytologically defined nuclear domains formed by clusters of peri
 centromeres from heterologous chromosomes) is one of the hallmarks of ESCs
 . The prevailing model for this permissive chromatin suggests a role in ma
 intaining genome accessibility and plasticity. In this talk\, I will prese
 nt evidence that an additional function for the open chromatin organisatio
 n in ESC is the maintenance of genome integrity through regulation of CH c
 lustering into large chromocentres. I will also explore how ESCs provide a
  valuable system to study the regulatory mechanisms involved in genome org
 anization and cell state maintenance. \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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