BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:‘Multi-dimensional cancer-immune cell interaction during metasta
 sis’ - Xiang Zhang\, Baylor College of Medicine\, Houston\, USA
DTSTART:20190227T120000Z
DTEND:20190227T130000Z
UID:TALK119419@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:The co-evolution between cancer and the immune system during m
 etastasis is dynamic and versatile. In syngeneic mammary tumor models\, we
  discovered unexpected functions of type I T helper cells and NK cells in 
 shaping the metastasis process. The former prevents metastasis by promotin
 g vessel normalization\, a process involving improved pericyte attachment 
 to endothelium\, increased blood perfusion\, decreased vessel permeability
 \, and consequently mitigated hypoxia. The latter exerts selective pressur
 es for CTC-clustering and polyclonal metastasis seeding\, by eliminating s
 ingle cell CTCs that have presumably lost epithelial traits. Therapies aug
 menting T cell and NK cell functions efficiently restrict metastases\, alt
 hough resistance often develops through multiple mechanisms including accu
 mulation of myeloid-derived suppressor cells. Our research uncovered spati
 otemporally specific interactions between cancer cells and various immune 
 cells\, and cries for in-depth investigations on collective activities of 
 multiple cell types beyond cytotoxic T cells.
LOCATION:Clifford Albutt Lecture theatre\, Clinical School
END:VEVENT
END:VCALENDAR