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CATEGORIES:Biophysical Seminars
SUMMARY:Investigating the propagation and spreading of pro
 tein aggregates in C. elegans - Carmen Nussbaum-Kr
 ammer\, Zentrum für Molekulare Biologie der Univer
 sität Heidelberg (ZMBH)
DTSTART;TZID=Europe/London:20190320T103000
DTEND;TZID=Europe/London:20190320T113000
UID:TALK118978AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/118978
DESCRIPTION:Many neurodegenerative diseases such as Alzheimer’
 s disease or Parkinson’s disease are associated wi
 th the gradual accumulation and characteristic spr
 eading of pathological proteins. Mechanisms underl
 ying the prion-like propagation of protein aggrega
 tes remain\, however\, largely elusive. I will pre
 sent our ongoing work using the nematode Caenorhab
 ditis elegans as a model system to discover and ex
 amine cellular pathways and factors that influence
  the propagation and intercellular spreading of di
 sease-associated proteins (e.g.\, α-Synuclein) in 
 metazoans. A better understanding of these mechani
 sms might eventually identify new druggable target
 s for the treatment of neurodegenerative diseases.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lec
 ture theatre
CONTACT:Gabriella Heller
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