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CATEGORIES:Cancer Research UK Cambridge Institute (CRUK CI) S
 eminars in Cancer
SUMMARY:Transcriptional dependencies in cancer - Christoph
 er Vakoc\, Cold Spring Harbor Laboratory
DTSTART;TZID=Europe/London:20191011T130000
DTEND;TZID=Europe/London:20191011T140000
UID:TALK117466AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/117466
DESCRIPTION:A reprogrammed transcriptional state is required f
 or malignant transformation\, a process that can r
 ender cancer cells addicted to specific transcript
 ional regulators. Our research focuses on identify
 ing transcriptional addictions in cancer using gen
 etic screens\, followed by a deep investigation of
  underlying mechanisms. Over several years\, our s
 tudies have reinforced the role of sequence-specif
 ic DNA binding transcription factors as the premie
 r transcriptional addictions deserving of therapeu
 tic intervention\, such as MYB in acute myeloid le
 ukemia and POU2F3 in small cell lung cancer. Howev
 er\, such targets are among the most challenging t
 o target directly with small-molecules\, which has
  motivated our efforts to study how TF oncoprotein
 s interact with their cofactors\, such BRD4\, p300
 \, TFIID\, and Mediator. My presentation will disc
 uss two of our recently identified transcriptional
  addictions in cancer identified via genetic scree
 ns and our efforts aimed at revealing properties t
 hat distinguish effective from ineffective transcr
 iptional therapies.
LOCATION:CRUK CI Lecture Theatre
CONTACT:Kate Davenport
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