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SUMMARY:Mechanism of transformation of neural stem cells by fusion onco-pr
 oteins. - Robert Kupp (CRUK Cambridge Institute / Oncology)
DTSTART:20181115T131000Z
DTEND:20181115T140000Z
UID:TALK111439@talks.cam.ac.uk
CONTACT:Miguel Anaya
DESCRIPTION:Ependymomas are tumors of the central nervous system\, arising
  within the ependymal lining at the ventricle-parenchyma interface. Molecu
 lar profiling studies suggests ependymomas in different anatomical compart
 ments are distinct and disparate diseases\, with unique cells of origin an
 d genetic drivers. We have recently described a highly recurrent 11q struc
 tural variant\, producing a fusion translocation between the C11orf95 gene
  of unknown function and RELA\, the principal effector of NF-kB signaling.
  C11orf95-RELA Fusion proteins\, when introduced into neural stem cells\, 
 rapidly transform to form ependymoma. Furthermore\, recent studies analyzi
 ng the genomes and transcriptomes of 500 primary ependymomas have reinforc
 ed these findings\, showing that C11orf95-RELA fusion proteins are found w
 ithin ~70% of forebrain (supratentorial) ependymomas and correlated with n
 egative overall survival. However\, the molecular events preceding and fol
 lowing Fusion transformation remain largely unknown. In this study we will
  present our recent efforts integrating transcriptome\, proteome\, interac
 tome\, and genome wide mapping of Fusion proteins (as well as their indivi
 dual components) to understand the mechanisms by which neural stem cells t
 ransform to form ependymomas. 
LOCATION:The Richard King Room\, Darwin College
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