BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Babraham Seminar
SUMMARY:EU Life Lecture - Temporal scaling of C. elegans A
 geing - Dr Nicholas E. Stroustrup\; Group Leader -
  Dynamics of Living Systems\, Centre for Genomic R
 egulation (CRG)\, Barcelona\, Spain
DTSTART;TZID=Europe/London:20181211T140000
DTEND;TZID=Europe/London:20181211T150000
UID:TALK111250AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/111250
DESCRIPTION:Ageing produces a wide distribution of lifespan ev
 en among isogenic individuals housed in controlled
  environments. Using our automated imaging platfor
 m\, we found that many lifespan-extending interven
 tions produce a similar effect on the C. elegans l
 ifespan distribution--a temporal scaling. Interven
 tions that produce this apparent stretching in res
 pect to time include changes in diet and temperatu
 re\, exposure to oxidative stress\, and the disrup
 tion of genes including the insulin/IGF receptor\,
  HSF-1\, and DAF-16/FOXO.\n\nThese interventions a
 ll produce distinct molecular-level changes\, yet 
 ultimately yield a similar scaling of the aging dy
 namics.  To understand this phenomenon\, we ran a 
 series of simulations in which we found that tempo
 ral scaling can arise as a general response of hig
 hly-interconnected complex networks.  When compone
 nts (e.g molecular mechanisms) are embedded in hig
 hly-interconnected networks\, declines in the func
 tion of small sub-networks can propagate to yield 
 a homogeneous effect on the dynamics of the system
  as a whole.  These results a provide a new\, empi
 rically-grounded framework for linking molecular i
 nterventions to their systemic effects in aging.
LOCATION:Babraham - The Cambridge Building - The Kings Hedg
 es Room
CONTACT:Bobbie Claxton
END:VEVENT
END:VCALENDAR