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SUMMARY:Neuronal Intrinsic and Extrinsic Factors Modulating Axon Growth Af
 ter Spinal Cord Injury in Young and Aged Mice - Cédric G Geoffroy - Texas
  A&M University
DTSTART:20180911T104500Z
DTEND:20180911T114500Z
UID:TALK108577@talks.cam.ac.uk
CONTACT:Dr Romina Vuono
DESCRIPTION:The capacity for axon growth after injury is limited in the ad
 ult mammalian\ncentral nervous system. This is attributed to both neuronal
 -extrinsic and\nintrinsic factors. The first part of this presentation wil
 l present how\nmodulating extrinsic factors (e.g. the myelin inhibitors su
 ch as Nogo\, MAG and\nOMgp) and intrinsic factors (e.g. PTEN)\, alone or i
 n combination\, can impact\naxon regeneration and sprouting and functional
  recovery after spinal cord\ninjury. The second part will focus on the eff
 ect of age on axon growth after\nSCI. Indeed\, very little is known about 
 how age influences the way the spinal\ncord responds to injury. We recentl
 y demonstrated an age-dependent decline in\nCNS axon regeneration accompan
 ied by changes of neuron-extrinsic factors at the\ninjury site\, implicati
 ng an increasing level of inhibitory influences at\nincreasing ages. These
  data have important implications on therapeutic\ndevelopment for spinal c
 ord injury and a variety of other CNS conditions with\naxonal pathologies.
LOCATION:James Fawcett Seminar Room\, van Geest Building
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