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SUMMARY:Precision and Plasticity in Animal Transcription - Angela DePace (
 Harvard Medical School)
DTSTART:20180410T130000Z
DTEND:20180410T140000Z
UID:TALK103819@talks.cam.ac.uk
CONTACT:Dr David Jörg
DESCRIPTION:Transcription is orchestrated by multiple types of regulatory 
 proteins binding to DNA\, but we do not yet understand how such binding ev
 ents are integrated to give rise to specific gene expression patterns. The
 oretical models of transcription can play a key role in deciphering how bi
 nding events are integrated by making our assumptions explicit and definin
 g the limits of those assumptions. The dominant theoretical models for tra
 nscription rely on a number of simplifying assumptions that I will challen
 ge. The first assumption is that regulatory DNA is modular (and thus can b
 e considered independently of the rest of the genome). The second assumpti
 on is that transcription is controlled by a single rate limiting step (thu
 s allowing it to be approximated by an equilibrium process). I will discus
 s how our recent theoretical and experimental work addresses these ideas d
 irectly\, and strategies for developing quantitative frameworks that can a
 ccommodate critical features of eukaryotic gene regulation\, such as locus
  topology\, chromatin modification and remodeling.
LOCATION:Part II Lecture Theatre\, Department of Zoology\, Downing Street\
 , Cambridge CB2 3EJ
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