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SUMMARY:Versatility and dynamics of transcriptional responses to Notch - P
 rofessor Sarah Bray from Department of Physiology Development and Neurosci
 ence\, University of Cambridge 
DTSTART:20180426T130000Z
DTEND:20180426T140000Z
UID:TALK102493@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Transcriptional changes elicited by signalling are key to many
  developmental and pathological processes. Often these are considered only
  in terms of simple static patterns of on/off gene expression\, I will dis
 cuss two ongoing projects that highlight the importance of looking beyond.
  First\, investigating the maintenance of Drosophila muscle progenitors we
  discovered that signaling switches the type of RNA produced\; Notch activ
 ity directs muscle progenitors to produce an alternate zfh1/ZEB1 RNA-isofo
 rm that protects them from differentiation. Second\, using the MS2/MCP sys
 tem to live-image transcription in real-time from two Notch responsive enh
 ancers we reveal that signaling elicits highly dynamic profiles of transcr
 iption and how these differ according to other spatial inputs.
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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