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Robert Kozarski, AstraZeneca
Thursday 26 April 2018, 19:15-21:30
Statistical Methods in Pre- and Clinical Drug Development: Tumour Growth-Inhibition Model Example
- đ¤ Speaker: Robert Kozarski, AstraZeneca
- đ Date & Time: Thursday 26 April 2018, 19:15 - 21:30
- đ Venue: Amgen Ltd, Cambridge Science Park, CB4 0WG
Abstract
Modelling of tumour-related outcomes to assess treatment efficacy applies in both pre- and clinical drug development. Stein et al. [2008] proposed a new paradigm to evaluate cancer therapy effectiveness in an early clinical drug development. The model decomposes the observed individual tumour measurements over time into two independent component processes of a constant exponential tumour growth/regrowth and regression (inhibition). The model was also found relevant in modelling pre-clinical in-vivo experimental data, establishing a novel approach in describing the observed tumour volume dynamics beyond a current practice. During the talk, the model pros and cons will be addressed with an example efficacy assessment of the Antibody Drug Conjugate (ADC) cancer therapies on a single study and database meta-analysis level.
Series This talk is part of the Cambridge Statistics Discussion Group (CSDG) series.
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