Skipping between Portals: neutron analysis of membrane protein biogenesis

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• Dr Nathan R. Zaccai -Cambridge Institute for Medical Research
• Friday 04 November 2016, 17:45-19:10
• Wolfson College, Gatsby Room.

If you have a question about this talk, please contact Dr Armando Maestro.

Contrast Variation Small Angle Neutron Scattering (SANS) has provided important insights into the biogenesis of membrane proteins in Gram-negative bacteria. Their cell envelope consists of two membranes, which differ with respect to their lipid composition, but also in the structure of their integral membrane proteins. Importantly, the latter are synthesised in the cytoplasm and therefore have to be transported to their correct membrane. SANS analysis of integral membrane translocons and soluble chaperones involved in this process have clarified the molecular basis of biological function, as well as revealed unexpected conserved mechanisms present in eukaryotic organisms.

This talk is part of the Wolfson College Science Society series.

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