Spatial simulation and analysis of actin filament dynamics and wave propagation

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• Kevin Sanft (University of North Carolina )
• Tuesday 21 June 2016, 14:45-15:30
• Seminar Room 1, Newton Institute.

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SDBW04 - Spatially distributed stochastic dynamical systems in biology

Co-authors: Hans Othmer (University of Minnesota), Yougan Cheng (University of Minnesota)

Actin filaments play an important role in many cellular processes, including cell motility. We present a stochastic model of actin filament dynamics in a three-dimensional Cartesian domain. Actin monomers bind to nucleation sites on the membrane and polymerize to form filaments (F-actin). F-actin polymers interact with membrane-bound nucleation promoting factors via a positive feedback loop. The resulting model produces waves of actin filaments that propagate along the membrane. Simulating polymer growth presents challenges to traditional Gillespie-type simulations. We describe a rule-based simulation approach to handle the many states of actin filament growth. Finally, we discuss techniques for managing the simulation output data.

This talk is part of the Isaac Newton Institute Seminar Series series.

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