Interacting-Particle Reaction-Diffusion Simulations: Endocytosis
- 👤 Speaker: Frank Noe (Freie Universität Berlin)
- 📅 Date & Time: Tuesday 21 June 2016, 11:00 - 11:45
- 📍 Venue: Seminar Room 1, Newton Institute
Abstract
We have introduced interacting-particle reaction-diffusion (iPRD) simulations as a hybrid between molecular dynamics simulations and particle-based reaction-diffusion simulations. iPRD is a suitable modeling framework for many cellular signaling processes, especially such processes involving dense protein mixtures, supramolecular architectures or protein scaffolds at membranes. I will introduce to the theory behind iPRD and present computational algorithms.
One of our key application areas is clathrin-mediated endocytosis in neurons, and I will briefly elude to simulations of protein recruitment to clathrin-coated pits and the interplay between membrane-associated proteins and membrane deformation in endocytosis.
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Frank Noe (Freie Universität Berlin)
Tuesday 21 June 2016, 11:00-11:45