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Structural Analysis of Genomic Scale Metabolic Networks

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If you have a question about this talk, please contact Nicholas Luscombe.

I will outline the principles of metabolic modelling and the distinction between kinetic and structural models. Since kinetic modelling is not yet practicable for large metabolic networks, the rest of the talk will focus on structural modelling techniques such as elementary modes analysis and enzyme subset analysis. I will illustrate the applications of these techniques, such as pathway discovery, before considering some of the issues involved in scaling up to large networks based on genome annotations and database information. Finally I will present evidence that structural analysis can complement the annotation and transcriptional study of genes for metabolic enzymes.

This talk is part of the European Bioinformatics Institute series.

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