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Fishing for the genetic basis of skeletal evolution and disease

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If you have a question about this talk, please contact Marcia Kishida .

Skeletal development is a fundamental biological process that has a major impact on human health, yet the genetic mechanisms that regulate the formation of each and every uniquely shaped bone are largely unknown. We take advantage of the dramatic skeletal differences between vertebrates to ask what genes regulate bone traits? What are the changes in those genes? Are the same mechanisms used when the same traits independently evolve in many species? Which sequence changes make our skeletons uniquely human? To begin to answer these long-standing questions in evolutionary biology, we use multipronged approach that combines work in two experimental systems, the threespine stickleback and mouse models, and comparative genomics of humans and other vertebrates. Examples of our studies to uncover the genetic basis of stickleback and human-specific skeletal traits will be illustrated during the seminar.

This talk is part of the Evolution and Development Seminar Series series.

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