Abstract

Friday 27 March, 13:00 – 14:00

Speaker: Professor Gopal Sapkota

Talk Title: Induced-proximity approaches for targeted protein degradation and dephosphorylation

Biography: The past research in my lab has identified some key molecules in the regulation of the TGF β/BMP pathways and opened up hugely promising avenues for further research on understanding their precise modes of action. My current and future research aims to build on the most exciting discoveries that my group has made and bolster the molecular understanding of their function, regulation and significance to human diseases, particularly cancer. Much of the work involves understanding their role and regulation through phosphorylation and ubiquitylation processes. I hope the findings will provide a framework of understanding and potential targets that could be exploited for therapeutic intervention against diseases such as cancer.The past research in my lab has identified some key molecules in the regulation of the TGF β/BMP pathways and opened up hugely promising avenues for further research on understanding their precise modes of action. My current and future research aims to build on the most exciting discoveries that my group has made and bolster the molecular understanding of their function, regulation and significance to human diseases, particularly cancer. Much of the work involves understanding their role and regulation through phosphorylation and ubiquitylation processes. I hope the findings will provide a framework of understanding and potential targets that could be exploited for therapeutic intervention against diseases such as cancer.