Gene-environment equivalence: the fundamental principle of Mendelian randomization
- đ¤ Speaker: George Davey Smith (University of Bristol)
- đ Date & Time: Wednesday 21 January 2026, 14:00 - 14:45
- đ Venue: Seminar Room 1, Newton Institute
Abstract
This talk will advance the notion of gene-environment equivalence as the fundamental principle of Mendelian randomization, from when it was introduced as an approach to strengthen causal inference regarding potentially modifiable factors influencing human development and disease. The biological basis and dimensions of equivalence will be presented, and its relation to the consistency /treatment–variation irrelevance assumptions in causal inference. The sanity-checking aspects of gene-environment equivalence can be further extended through incorporating recent advances in the molecular biology of gene action.
Series This talk is part of the Isaac Newton Institute Seminar Series series.
Included in Lists
- All CMS events
- bld31
- dh539
- Featured lists
- INI info aggregator
- Isaac Newton Institute Seminar Series
- School of Physical Sciences
- Seminar Room 1, Newton Institute
Note: Ex-directory lists are not shown.
![[Talks.cam]](/static/images/talkslogosmall.gif)

George Davey Smith (University of Bristol)
Wednesday 21 January 2026, 14:00-14:45