Building and extending the body axis: the role of tissue Interfaces

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• Pierre-François Lenne, IBDM and Turing Center for Living Systems, Aix Marseille Univ. & CNRS, Marseille, France
• Monday 20 October 2025, 14:30-15:30
• in person at Sainsbury Laboratory and online.

If you have a question about this talk, please contact Jia CHEN.

Abstract:

The formation of the body axis is a central step in embryonic development; however, how tissues coordinate to shape and extend it remains largely unknown. Using mouse gastruloids and Xenopus explants, we investigated how tissue interactions drive axis elongation. In gastruloids, we demonstrate that the mechanical properties at tissue interfaces drive collective cell flows and contribute to axis formation and early extension. In Xenopus explants, we show that coordinated interactions between epithelial and mesenchymal layers are essential for robust elongation. These findings highlight different but potentially conserved strategies by which tissues build and extend the body axis, revealing that tissue interfaces can organize coherent axis formation even in the absence of external signals.

This talk is part of the Morphogenesis Seminar Series series.

This talk is included in these lists:

• Graduate-Seminars
• Morphogenesis Seminar Series
• in person at Sainsbury Laboratory and online

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