Structure, Kinetics, and the Identification of Integrated Control in Neuronal Excitability

Add to your list(s) Download to your calendar using vCal

• Prof Shimon Marom, Technion
• Thursday 19 June 2025, 14:00-15:00
• Cambridge University Engineering Department, Lecture Room 6.

If you have a question about this talk, please contact Prof Timothy O'Leary.

Due to events beyond our control, this talk will be live streamed to the talk venue

The regulation of neuronal excitability is frequently associated with structural parameters, such as the densities of ion channel proteins. This presentation introduces a complementary mode of regulation—kinetic-based control—in which membrane channel functional availability reflects the history of activation over extended timescales, irrespective of protein synthesis or degradation. This distinction between structure and kinetics challenges conventional models of excitability control, which presume separable system components and predefined targets. In physiological systems, where observables, sensors, and actuators are integrated within the same molecular substrates, conventional decomposition-based approaches fall short. I propose and demonstrate the use of closed-loop methodological designs as a means for studying regulation of excitability under such conditions.

This talk is part of the Bioengineering series.

This talk is included in these lists:

• Cambridge University Engineering Department, Lecture Room 6
• Bioengineering

Note that ex-directory lists are not shown.