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Analysis and perturbation of cell behaviours controlling gastrulation in the chick embryo

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SPLW02 - Active mechanics, from single cells to cell layers, tissues and development

Gastrulation is an essential process in the development of animals, including humans. It is characterized by highly coordinated tissue movements and deformations at the scale of the embryo to set up the basic body plan. We have been able to quantitatively analyze the detailed cell behaviours that underly the process of gastrulation in the chick embryo, using a combination of lightsheet microscopy-based live imaging, large-scale computational data analysis and modelling. I will describe ongoing experimental work to understand the signals that coordinate critical cell and tissue behaviours and show how they can be manipulated to achieve different modes of gastrulation.

This talk is part of the Isaac Newton Institute Seminar Series series.

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