Functional Imaging via Diffuse Correlation Spectroscopy and Speckle-Based Methods

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• Nisan Ozana
• Friday 05 May 2023, 14:00-15:00
• Electrical Engineering, Department of Engineering - EE Seminar Room, 9 JJ Thomson Avenue, Cambridge, CB3 0FA.

If you have a question about this talk, please contact Kirsty Shepherd.

Functional neuroimaging plays a key role in understanding the neural circuitry and fundamental mechanisms of the brain. Advancements in diffuse optics, Light Detection and Ranging (LiDAR) and astronomy imaging systems are fostering the development of new instruments and techniques for non-invasive real-time optical and acoustical neuroimaging. Recently the advantage of diffuse optical methods for functional and clinical neuroimaging was shown via the following methods. The first method is based on superconducting nanowire single photon detectors (SNSPDs) and illumination at 1064nm, which offer superior photon efficiency, timing resolution, dark count rate, broad wavelength sensitivity, and low after-pulsing probability. Initial human results show a 16- fold improvement in SNR and 20% improvement in depth sensitivity. The second approach, based on time-domain system allow rejection of short pathlength photons that travel mostly in extracerebral layers i.e. scalp and skull and allow selection of longer pathlength photons that travel in the deeper brain layer. The last method is based on lowcost detection using multi-speckle sensing which enables high speed (>50Hz) and high SNR measurements of cerebral blood flow.

This talk is part of the Electrical Engineering series.

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• Electrical Engineering
• Electrical Engineering, Department of Engineering - EE Seminar Room, 9 JJ Thomson Avenue, Cambridge, CB3 0FA

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