Sleep and dementia, developing precision management and prevention of cognitive decline- the TIMES programme 2022-2027

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• Prof Chris Fox, University of Exeter
• Tuesday 10 May 2022, 11:25-12:15
• please contact mho28@medschl.cam.ac.uk.

If you have a question about this talk, please contact .

ARUK East Network Centre Scientific Meeting 2022

Abstract: Background: In the UK, there are 850,000 People Living With Dementia and 2.4 million people with Minor Cognitive impairment. Sleep problems are common in Dementia of all types (20-90%) and Minor Cognitive Impairment (18.3–45.5%). There are no licensed medications for this and medicines used have harms. Sleep management in people with cognitive impairment is an example of a ‘wicked design problem’ because the problem is complex, the knowledge required to understand and address it includes multiple disciplines and subject expertise, and because interventions do not ‘fix’ but support best management in context.

The cause of sleep disturbance in this population is multifactorial:

• Age-related changes e.g. lower sleep efficiency, weakening of circadian entrainment, visual impairment, contributing to sleep-wake rhythm abnormalities.
• Psychological disorders e.g. stress, anxiety or depression.
• Medicine side effects e.g. Donepezil (medicine licensed for dementia) and nightmares.
• Co-morbidities e.g. arthritis, heart failure, reflux and obstructive sleep apnoea. *Environmental factors e.g. excessive nocturnal noise or light, low daytime light exposure, uncomfortable room temperature, polution and nocturnal care practices.
• Activity levels e.g. reduced physical activities, social disengagement and daytime napping.

In this presentation we will consider the following key issues:

1. Sleep
2. Sleep in dementia/MCI
3. Prevention of dementia and sleep
4. Harms of medication in dementia/mci
5. Suggested solution in dementia/mci
6. TIMES prototype

This talk is part of the Alzheimer's Research UK East Network Centre series.

This talk is included in these lists:

• Alzheimer's Research UK East Network Centre
• please contact mho28@medschl.cam.ac.uk

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