University of Cambridge > Talks.cam > Microglia webinar series > More the bystanders: Learning how microglia eliminate synapses in the Alzheimer brain

More the bystanders: Learning how microglia eliminate synapses in the Alzheimer brain

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My lab’s research is aimed at identifying whether, and if so how, tissue-resident macrophages of the brain and gut contribute to synaptic homeostasis in health and pathology in neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD). One key question my lab is addressing is whether tissue-resident macrophages including microglia exist in diverse functional clusters, and if so, which ones contribute to neuronal dysfunction in disease using spatial omic approaches. A second major question of my lab is to understand whether microglia target synapses or neuronal elements for engulfment in the diseased brains, and if so, which ones. To this end, we are manipulating neuronal circuit activity and lipid/Trem2 signaling pathways as well as assessing the role of astrocytes in microglia-mediated synapse elimination. These findings will help broaden our understanding of how neuroimmune interactions may go awry during aging and dementia.

This talk is part of the Microglia webinar series series.

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