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The chromatin response of human cells to SARS-CoV-2 et al

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  • UserDr Ritwick Sawarkar; Group Leader, MRC Toxicology Unit, University of Cambridge
  • ClockWednesday 31 March 2021, 15:00-16:00
  • HouseZoom Seminar.

If you have a question about this talk, please contact Bobbie Claxton.

This webinar will be online via zoom. No registration required.

A variety of environmental stressors and infections cause global transcriptional downregulation in human cells, a phenomenon we termed as Stress-Induced Transcriptional Attenuation (SITA). In the talk, I will discuss our work on understanding the mechanism underlying SITA that has led us to uncover novel nuclear condensates formed by liquid-liquid phase separation. Similar transcriptional downregulation is also seen in lung cells upon SARS -CoV-2 infection, identifying therapeutic avenues.

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