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Cone subtype specification in human retinal organoids

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  • UserDr Robert Johnston, Department of Biology, Johns Hopkins University, Baltimore
  • ClockThursday 21 January 2021, 14:00-15:00
  • HouseZoom meeting.

If you have a question about this talk, please contact Caroline Newnham.

Host: Hansong Ma

In humans, three subtypes of cone photoreceptors enable trichromatic color and high acuity vision. To overcome the challenges associated with studies of human development, we utilized a human organoid system that recapitulates retinal development and photoreceptor specification. We found that spatiotemporal regulation of thyroid hormone and retinoic acid signaling specifies cone subtypes in human retinal organoids. Our studies advanced human retinal organoids as a model for revealing mechanisms of human development, with promising utility for therapeutics and vision repair.

This talk is part of the Genetics Seminar series.

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