Mitochondria and Cancer: Metabolites and Beyond

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• Christian Frezza, University of Cambridge
• Friday 14 February 2020, 16:00-17:00
• Ryle Seminar (Rutherford 930).

If you have a question about this talk, please contact Diana Fusco.

The role of mitochondrial dysfunction in cancer has been debated for over a century. Recent bioinformatic data analyses revealed that mitochondrial genes are suppressed in cancer with poor clinical outcome. Furthermore, the fact that mutations of core metabolic enzymes in the mitochondria such as Fumarate Hydratase (FH) cause renal cancer strongly indicates that mitochondrial dysfunction can drive cancer. Today, I will provide an overview of our recent findings about the molecular mechanisms through which mitochondrial dysfunction caused by the loss of FH can drive transformation and shape cancer progression.

This talk is part of the Biological and Biomedical Physics series.

This talk is included in these lists:

• All Cavendish Laboratory Seminars
• Biological and Biomedical Physics
• Centre for Health Leadership and Enterprise
• Featured lists
• ME Seminar
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• Ryle Seminar (Rutherford 930)
• School of Physical Sciences
• Thin Film Magnetic Talks

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