Cambridge Haematopoiesis Seminars 2010-06-04 16:00: In vivo imaging of haematopoietic stem and progenitor cells interacting with their niche(s) (Cristina Lo Celso, Imperial College, London) 2010-06-11 16:00: Interactions between a cell signalling pathway and a haematopoietic transcriptional network (John Pimanda, University of New South Wales) 2010-07-29 13:00: Modeling APL pathogenesis through therapy response (Hugues de Thé MD, PhD, University of Paris, Head, INSERM/CNRS/University Paris 7) 2010-09-09 16:00: Initiation and progression of leukemia – lessons from Down Syndrome (Shai Izraeli, Tel Aviv University, Israel) 2010-10-15 16:00: Leukemic stem cells - a challenging adversary (Keith Humphries, Terry Fox Laboratories, Vancouver, Canada) 2010-11-11 15:00: Insights into the molecular basis of myelodysplastic syndrome (Ben Ebert, Department of Medicine, Harvard Medical School) 2011-02-25 16:00: Genetic complexity in MPN and MDS/MPN (Nick Cross, Univeristy of Southampton) 2011-04-18 10:30: Studying precancerous stem cells in mouse models of T cell leukaemia (Matthew McCormack, WEHI, Melbourne) 2011-05-13 16:00: The development of HSCs: endothelial to hematopoietic transition (Elaine Dzierzak, Erasmus MC, Rotterdam) 2011-06-09 13:30: Genetics and therapy of AML: role of mutations in the epigenetic machinery (Ross Levine, Memorial Sloan-Kettering, New York) 2011-06-17 16:00: Why do we need a Fanconi Anaemia DNA repair pathway? (KJ Patel, MRC LMB, Cambridge) 2011-07-06 10:00: Development of hematopoietic stem cells: an outline of the final scenario (Shin-Ichi Nishikawa, Riken CDB, Kobe) 2011-09-16 16:00: Genome-wide DNA methylation analysis in stem cells and cancer (Christoph Bock, Broad Institute) 2011-09-23 16:00: Chromatin, chromosome and nuclear dynamics, links to genome function (Peter Fraser, Babraham Institute) 2011-11-07 16:00: Long non-coding and extracoding RNAs in normal haematopoiesis and leukemia (Dan Tenen, Cancer Science Institute of Singapore and Harvard Medical School) 2011-12-06 16:00: Commitment and plasticity in the B cell lineage (Research Institute of Molecular Pathology Vienna, Austria) 2012-01-27 16:00: How do enhancers and promoters interact and what are the consequences ? (Doug Higgs, Weatherall Institute, Oxford,) 2012-03-23 16:00: Local interactions and genome-wide co-associations of proto-oncogenes: the short and the long of it. (Cameron Osborne, Babraham Institute) 2012-05-11 16:00: Immune cell transdifferentiation (Thomas Graf, Centre for Genomic Regulation (Barcelona)) 2012-10-15 16:00: Tet proteins and methylcytosine oxidation (Anjana Rao, La Jolla Institute for Allergy and Immunology) 2012-10-19 16:00: Genome-wide mapping of DNA rearrangements in single cells using DNA template strand sequencing (Peter Lansdorp, European Research Institute on the Biology of Ageing, University of Groningen) 2012-10-30 13:00: The Aging of Hematopoietic Stem Cells (David Bryder, Lund University) 2012-11-30 16:00: Epigenetic reprogramming in mammalian development (Wolf Reik) 2013-05-03 11:00: Polycomb-mediated selfrenewal of young (and aged?) hematopoietic stem cells (Gerald de Haan, Scientific Co-Director, European Research Institute for the Biology of Ageing) 2013-09-18 11:00: Look Beyond the Target: How Lessons from Chronic Myeloid Leukaemia Can Improve Cancer Targeted Therapies (Assoc. Prof. Sin Tiong Ong, Duke-NUS Graduate Medical School Singapore & Duke University Medical Center) 2013-09-20 16:00: Molecular and cellular basis of disease initiation in myeloproliferative neoplasms (Prof. Radek Skoda, Head of the Department of Biomedicine, University Hospital, Basel) 2013-10-07 17:00: Forward genetic screening using patient CML cells identifies IKAROS as a myeloid tumour suppressor (Dr Philip Beer, Terry Fox Laboratory, Vancouver) 2013-10-15 16:00: Mutations in Epigenetic Modifiers in Myeloid Malignancies (Dr Ross Levine, Memorial Sloan-Kettering Cancer Center, New York) 2013-10-18 16:00: Bone marrow environment and platelet production (Assoc. Prof. Alessandra Balduini, University of Pavia Italy, and Tufts University USA) 2013-11-08 16:00: Emerging therapeutic strategies for treating the first molecular disease (Prof. James Douglas Engel, University of Michigan Medical School, USA) 2013-11-12 12:30: Haematopoietic Stem Cells (Prof. Connie Eaves, Terry Fox Laboratory, Vancouver) 2013-11-22 16:00: Cancer Epigenetics: Appreciating the beauty and complexity of a string of pearls (Mark Dawson, University of Cambridge) 2014-01-07 16:00: Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology (Bengt Hallberg (Umea University, Sweden)) 2014-02-07 16:00: 4D tracking of haematopoietic stem and progenitor cells in their bone marrow microenvironment (Dr Cristina Lo Celso, Imperial College London) 2014-03-07 13:00: Notch and Wnt Signaling: From Hematopoeitic Stem Cells to Leukemia (Anna Bigas. Cancer and Stem Cells Research Group. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)) 2014-03-14 11:00: Of mice and men and Tasmanian devils; assembling reference genomes from single cells. (Dr Mark Hills, Terry Fox Lab, Vancouver, Canada) 2014-03-21 16:00: Heterogeneity of hematopoietic stem and progenitor cell populations: implications for ageing and regeneration (Claus Nerlov, University of Oxford) 2014-04-04 16:00: Neuroendocrine regulation of the bone marrow stem-cell niche (Simón Méndez-Ferrer, CNIC, Madrid, Spain) 2014-04-22 15:00: Engaging mechanisms of negative B cell selection to overcome drug-resistance in leukaemia (Prof. Markus Müschen, UCSF) 2014-05-13 16:00: Familial thrombocytopenias with predisposition to leukemia: RUNX1 targets (Dr Hana Raslova, Institut Gustave Roussy, Paris) 2014-06-06 16:00: Regulation of Akt by the Sin1-mTOR complex in lymphocytes (Prof. Bing Su (Department of Immunobiology at Yale, and Shanghai Institute of Immunology at Shanghai JiaoTong University School of Medicine)) 2014-07-02 16:15: Normal and leukaemic (AML) human stem/progenitor cells (Prof. Paresh Vyas, WIMM, Oxford University) 2014-07-09 13:00: Dnmt3a in Normal and Malignant Hematopoiesis (Prof Margaret Goodell, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine) 2014-07-14 16:00: Targeting survival pathways in CML stem cell persistence and TKI-resistance (Prof. Tessa Holyoake, University of Glasgow) 2014-09-08 16:00: Aurora A kinase and RPS14: new players in the myeloproliferative neoplasms (Prof. John Crispino, Northwestern University, Chicago) 2014-09-19 16:00: Clinical and Biological Impact of Flt3 mutations in Acute Leukaemia (Dr Adam Mead, University of Oxford) 2014-10-16 16:00: Hematopoietic stem cell formation in the embryo (Prof. Nancy Speck, University of Pennsylvania) 2014-11-14 16:00: Mimicking of the process of human erythropoiesis using in vitro culture; studies on red blood cell membrane assembly and also use of 3D scaffolds (Dr Ashley Toye, University of Bristol) 2015-01-29 16:00: Opening up the stem cell niche for human and mouse hematopoietic stem cells (Prof. Claudia Waskow, Center for Regenerative Therapies TU Dresden) 2015-02-11 10:00: Predictive Engineering of Cell Fate (Prof. Peter Zandstra, University of Toronto) 2015-03-20 16:00: Aberrant chromatin programming in AML (Prof. Constanze Bonifer, University of Birmingham) 2015-05-08 16:00: Title to be confirmed (Prof. Frederic Geissman, Kings College London) 2015-05-20 13:00: Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis (Dr Nina Cabezas (DKFZ, Heidelberg)) 2015-06-05 16:00: Making Hematopoietic Stem Cells: Backwards and Sideways (Dr Derrick Rossi (Harvard, USA)) 2015-06-17 11:00: Insights into mammalian hematopoiesis from comparative functional genomic (Prof. Ross Hardison (Penn State)) 2016-01-18 16:00: Sub-clonal heterogeneity in chronic myeloid leukemia (Mike Schmitt - Fred Hutchinson Cancer Research Centre, University of Washington) 2016-01-20 16:30: Placing BETs on hold in AML (Mark Dawson - Peter MacCallum Cancer Centre, Melbourne, Australia) 2016-03-08 10:00: Single-cell analysis of hematopoietic stem cell identity and behaviour (David Knapp -- Terry Fox Laboratory, Vancouver) 2016-03-10 17:00: Cambridge Haematopoiesis Seminars: Timm Schroeder & Ellen Rothenberg (Timm Schroeder - ETH Zurich & Ellen Rothenburg - Caltech) 2016-10-14 14:30: Structure vs. Function: A quantitative analysis of chromosome architecture (Luca Giorgetti - Friedrich Miescher Institute, Basel)