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CATEGORIES:Cambridge Neuroscience Seminars
SUMMARY:Ion Channels as Targets for CNS Disease - Prof. De
 rek Bowie\,Department of Pharmacology and Therapeu
 tics McGill University
DTSTART;TZID=Europe/London:20170620T160000
DTEND;TZID=Europe/London:20170620T170000
UID:TALK72954AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/72954
DESCRIPTION:The Bowie lab uses a combination of techniques to 
 study ionotropic glutamate receptors (iGluRs)\, GA
 BAA receptors and more recently\, Na+ channels. Al
 l ion channel families are widespread in the verte
 brate brain and fulfil many important roles in hea
 lthy individuals\, as well as being implicated in 
 disease states associated with postnatal developme
 nt (e.g. autism\, schizophrenia)\, cerebral insult
  (e.g. stroke\, epilepsy) and aging disorders (e.g
 . Alzheimer's disease\, Parkinsonism). Each ion-ch
 annel family is studied at two inter-related level
 s. In structural terms\, ion-channel activation me
 chanisms are examined to provide insight into deve
 loping novel therapeutic compounds. At the level o
 f brain circuits\, we are studying the role of ion
 -channels in CNS disease. The talk will focus on r
 ecent findings linking deficits in glutamatergic s
 ignaling to the neurodevelopmental disorder\, Frag
 ile-X syndrome.
LOCATION:Department of Pharmacology Lecture Theatre\, Tenni
 s Court Road
CONTACT:Dr Mike Edwardson
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