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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Mass Spectrometry Imaging in Drug Discovery: The C
hallenges and Opportunities for Molecular Imaging
from Single Cells\, Preclinical Models and Through
to Intraoperatively - Richard Goodwin (AstraZenec
a)
DTSTART;TZID=Europe/London:20170419T144000
DTEND;TZID=Europe/London:20170419T151500
UID:TALK72006AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/72006
DESCRIPTION:Mass spectrometry imaging (MSI) is impacting on mu
ltiple stages of drug discovery and supports estab
lished histopathology imaging. MSI offers the abil
ity to simultaneously map the distribution of endo
genous (metabolites\, lipids and peptides) and exo
genous compounds (drugs and their metabolites) dir
ectly from the surface of tissue section. This can
offer new routes into understanding drug efficacy
and safety. The suite of MSI technologies that wi
ll be described are also capable of allowing trans
lation into the clinic through analysis of patient
biopsies and surgically collected tissues. Presen
ted will be an overview of MSI in a drug discovery
environment\, showcasing the current state of the
art MSI technology platforms. We will also discus
s the challenges that remain in the data and image
analysis for this emerging molecular imaging moda
lity.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:INI IT
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