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CATEGORIES:Bacteriophage 2017
SUMMARY:A novel role for phage P22’s scaffolding protein: 
 triggering portal ring oligomerization and incorpo
 ration during procapsid assembly - Dr. Tina Motwan
 i\, University of Connecticut\, Storrs\, United St
 ates
DTSTART;TZID=Europe/London:20170117T160000
DTEND;TZID=Europe/London:20170117T163000
UID:TALK69679AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/69679
DESCRIPTION:The majority of DNA viruses package their genomes 
 into preformed precursor capsids through a portal 
 protein complex incorporated in the capsid at a si
 ngle vertex. The existence of a unique portal comp
 lex is crucial to the formation of mature infectio
 us virions\, but how only one portal assembly is s
 electively incorporated at a special vertex is unc
 lear. Here\, we show incorporation of bacteriophag
 e P22 portal protein into PC in vitro as pre-assem
 bled dodecameric rings. A novel role for the scaff
 olding protein in triggering portal ring formation
  from portal monomers was also found. Thus\, new d
 etails are revealed about this critical step in th
 e assembly of icosahedral viruses that use a porta
 l protein in conjunction with a genome-packaging m
 otor to encapsulate their genetic material.
LOCATION:Online
CONTACT:Ilana Spilka
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