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CATEGORIES:Seminars at the Department of Biochemistry
SUMMARY:Why are tumours dependent on the MYC oncoprotein? 
 - Dan Lu\, Gerard Evan Lab\, Department of Biochem
 istry
DTSTART;TZID=Europe/London:20160318T140000
DTEND;TZID=Europe/London:20160318T150000
UID:TALK64932AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/64932
DESCRIPTION:Description: Cancers arise when cell-signalling pa
 thways\, which are normally tightly regulated\, be
 come disrupted. Tumours subsequently become depend
 ent on the expression of certain proteins\, someti
 mes referred to as “oncogene addiction”. Identific
 ation of these tumour-specific vulnerabilities\, a
 bsent from normal cells\, provides a therapeutic w
 indow. In this talk\, I provide molecular rational
 es on how inhibition of the MYC oncoprotein\, dere
 gulated in most if not all human cancers\, leads t
 o the regression of a multitude of tumour types (i
 ncluding lung\, pancreas and mammary).\n
LOCATION:Department of Biochemistry - Sanger Building\, Sem
 inar Room
CONTACT:
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