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CATEGORIES:Trinity Mathematical Society
SUMMARY:[TMS Symposium] Tissue mechanics in early brain de
 velopment - Joy Thompson
DTSTART;TZID=Europe/London:20160221T101500
DTEND;TZID=Europe/London:20160221T104500
UID:TALK64754AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/64754
DESCRIPTION:Neuronal growth is essential for nervous system de
 velopment and is also required for regeneration af
 ter\nnervous tissue injury. Recent in vitro studie
 s suggest that neuronal growth can also be regulat
 ed by\nmechanical properties of the substrate\; ho
 wever\, the role of mechanical cues in axon pathfi
 nding in\nvivo\, and the spatiotemporal dynamics o
 f tissue mechanics during early nervous system dev
 elopment\,\nare still largely unknown. I am invest
 igating the role of tissue stiffness in axon guida
 nce within the early\nembryo\, using the Xenopus l
 aevis optic tract as a model system. I find that t
 he path of optic tract\ngrowth is correlated with 
 stiffness gradients in the living brain\, before g
 rowth stalls after reaching the\nsofter region. Th
 is is consistent with a role for substrate mechani
 cs in axon pathfinding.\n
LOCATION:Winstanley Lecture Theatre\, Trinity College
CONTACT:Jason Kwong
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