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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Some critical issues in adaptive experimental desi
gns for treatment comparisons - Giovagnoli\, A (Un
iversity of Bologna)
DTSTART;TZID=Europe/London:20150706T141500
DTEND;TZID=Europe/London:20150706T150000
UID:TALK60046AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/60046
DESCRIPTION:The study of adaptive designs has received impetus
over the past 20 years\, mainly because of its po
tential in applications to clinical trials\, and a
large number of these designs is now available in
the statistical and biomedical literature\, start
ing from simple ones like Efrons Biased Coin Desig
n and Zelens Play-the-Winner\, to the more \nsoph
isticated ones: D_A-optimum Biased Coin designs\,
Doubly-Adaptive designs\, ERADE\, Randomly Rein
forced Urns\, Reinforced Doubly-Adaptive Biased C
oins\, etc.\, not forgetting covariates (Covariate
-Adjusted Response-Adaptive\, Covariate-Adaptive
Biased Coin\, Covariate-adjusted Doubly-adaptive B
iased Coin designs\, etc.).\n\nA complicating fact
or is that nowadays adaptive experiments are in ge
neral multipurpose: they try to simultaneously ac
hieve inferential efficiency\, bias avoidance\, an
d utilitarian or ethical gains. Another is the ver
y nature of an adaptive design\, which is a random
\nexperiment that may or may not converge to a fi
xed treatment allocation. \n\nThis talk does not
intend to be a survey of the existing literature\,
rather it is an effort to highlight potentially c
ritical points: inference after an adaptive experi
ment\, combined versus constrained optimization\,
speed of convergence to a desired target\, possibl
e \nmisuse of simulations. Each of these points
will be discussed with reference to one or more sp
ecific adaptive designs.\n
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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