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CATEGORIES:Plant Sciences Departmental Seminars
SUMMARY:Phylogenetic shadowing guided by the cycling trans
 criptomes of two distantly related Brassicaeae spe
 cies reveals the atlas of cis-regulatory elements 
 of daytime-specific and daytime-unspecific pathway
 s - Korbinian Schneeberger (Max Planck Institute f
 or Plant Breeding\, Cologne)
DTSTART;TZID=Europe/London:20131128T130000
DTEND;TZID=Europe/London:20131128T140000
UID:TALK47375AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/47375
DESCRIPTION:Recent genome comparisons of a growing number of B
 rassicaceae genome assemblies revealed the extent 
 of conserved non-coding sequences (CNS). Despite t
 hese evolutionary constraints\, little is known ab
 out their function. \nWe assembled the genome of A
 rabis alpina\, which diverged ~30 million years ag
 o from A. thaliana and sequenced the transcriptome
 s of both species at 12 time points of two consecu
 tive days. Over ~4\,000 orthologous genes showed d
 aytime-dependent expression. \nComprehensively ana
 lyzing CNS for cis-regulatory elements revealed 50
  putatively daytime specifying motifs\, including 
 all those shown to be involved in diurnal expressi
 on so far. Moreover\, absence or presence of many 
 elements has significant impact on the degree of c
 onservation in gene expression\, evidencing their 
 role in gene regulation.\nOn average diurnal genes
  are delayed by two hours in A. alpina as compared
  to A. thaliana. The plant circadian clock can be 
 divided into three intervening loops\, but intrigu
 ingly this shift is only present in the morning an
 d evening loops\, but not in the core loop. GO enr
 ichment and pathway analyses revealed striking dif
 ferences between pathways conserved for their dayt
 ime and those being shifted. Conserved pathways in
 clude photosynthesis and primary metabolite biosyn
 thesis\, whereas shifted pathways are enriched for
  secondary metabolites biosynthesis. 
LOCATION:Department of Plant Sciences\, Large Lecture Theat
 re
CONTACT:Ian Henderson
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