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CATEGORIES:Plant Sciences Research Seminars
SUMMARY:Phytic acid and plant defence responses - Jacquely
 ne Poon
DTSTART;TZID=Europe/London:20130426T123000
DTEND;TZID=Europe/London:20130426T130000
UID:TALK44277AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/44277
DESCRIPTION:Inositol hexakisphosphate (InsP6) has been suggest
 ed as a signalling compound in basal defence respo
 nses against pathogen invasion (Murphy et al. 2008
 ). Mutant Arabidopsis plants with reduced expressi
 on of Atips2 (inositol phosphate synthase 2)\, but
  not atips1 mutants\, were previously shown to hav
 e enhanced susceptibility to a range of pathogens\
 , including two RNA viruses (cucumber mosaic virus
  and turnip mosaic virus)\, a DNA virus (cauliflow
 er mosaic virus)\, a bacterium (Pseudomonas syring
 ae)\, and a necrotrophic fungus (Botrytis cinerea)
 . I am manipulating biochemical pathways leading t
 o InsP6 production to further understand the role(
 s) of inositol polyphosphates in plant defence. To
  test whether elevating InsP6 content enhances res
 istance to pathogens\, I am decreasing the express
 ion of myo-inositol oxygenase (MIOX)\, which is en
 coded by a small family of four Miox genes in Arab
 idopsis. Biosynthesis of InsP6 relies primarily on
  the bioavailability of its precursors\, myo-inosi
 tol and inorganic phosphate\, the former of which 
 is restricted by MIOX. MIOX converts inositol to g
 lucuronic acid\, directing biosynthesis towards po
 lysaccharide production. Arabidopsis plants with r
 educed MIOX expression were previously shown to ha
 ve increased InsP6 levels. I will then test atmiox
  mutants (single or multiple null allele) for effe
 cts on pathogen susceptibility and for effects on 
 signalling mediated by jasmonic acid and salicylic
  acid\, phytohormones with key roles in defence.
LOCATION:Biffen Lecture Theater\, Department of Genetics
CONTACT:Megan Cooper
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