BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Fluid Mechanics (DAMTP)
SUMMARY:Biochemical hydrodynamics of protein solutions wit
h high pressure relaxation kinetics - Gregory Vile
nsky (UCL)
DTSTART;TZID=Europe/London:20130315T160000
DTEND;TZID=Europe/London:20130315T170000
UID:TALK43298AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/43298
DESCRIPTION:This work aims to formulate a rational approach to
problems of biochemical hydrodynamics of protein-
solvent systems. The common feature of such probl
ems is the existence of the myriad of simultaneous
biochemical reactions with a broadband distributi
on of reaction rates. Normally\, the kinetic even
ts can be initiated by the disturbance of the syst
em from the state of thermodynamic equilibrium eit
her via the perturbation of the pressure\, the tem
perature or the chemical content of the solution.
This work considers the case of pressure induced
relaxation kinetics.\n\nTypically\, biochemical st
udies do not consider the effects of interaction b
etween hydrodynamic motions and kinetics. Being pr
imarily concerned with calculations of the reactio
n rates and other important characteristics of the
involved biochemical processes\, they represent t
he fluid state by means of effective steadystate v
alues. However\, when the relaxation times of the
involved microscopic kinetics occupy a broadband
interval\, hydrodynamic and kinetic time scales ma
y become comparable. In this situation the hydrod
ynamic state cannot be treated as passive to the k
inetic changes. Neither can the effects of kineti
cs on the hydrodynamics be schematically represent
ed by a small number of relaxation equations\, sin
ce this would contradict the broadband nature of t
he involved kinetics. Consequently\, one enters i
nto a new area of hydrodynamics in which modelling
of the interaction between the broadband protein
kinetics and nonequilibrium fluid motion is requir
ed. This work illustrates the distinctive feature
s of this new class of problems by considering the
practically important example of pressure initiat
ed fast relaxation kinetics in protein solutions.\
n\nOwing to the broadband distribution of the reac
tion rates\, the approach to modelling based on a
large number of ordinary differential equations of
reaction kinetics is impractical as it results in
a stiff system of governing equations. An altern
ative method is to use continuous distributions of
relaxation times\, in order to account for the ki
netic effects. This approach results in a compact
set of equations similar to the conventional Navi
er-Stokes-Fourier system\, but with additional ter
ms responsible for the production of entropy owing
to the biochemical changes of the medium's struct
ure.\n\nThis talk analyzes one such methodology fr
om the point of view of novel hydrodynamic effects
caused by pressure induced fast protein kinetics
which would not be observed if conventional equati
ons of fluid mechanics were used.\n
LOCATION:MR2\, Centre for Mathematical Sciences\, Wilberfor
ce Road\, Cambridge
CONTACT:Dr Ed Brambley
END:VEVENT
END:VCALENDAR