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CATEGORIES:Genetics Seminar Series
SUMMARY:Bending the not so simple mind of the fruit fly - 
 Scott Waddell Ph.D Professor of Neurobiology\, Uni
 versity of Oxford
DTSTART;TZID=Europe/London:20120510T143000
DTEND;TZID=Europe/London:20120510T153000
UID:TALK37503AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/37503
DESCRIPTION:Directed behaviour emerges from neural integration
  of sensory stimuli\, memory of prior experience a
 nd internal states. We seek an understanding of th
 ese conserved neural mechanisms using genetically-
 encoded tools and the relatively small brain of Dr
 osophila. By temporally controlling neural functio
 n memories can be implanted and internal states al
 tered so that most flies behave according to our d
 irection. Such recent studies have revealed a role
  for distinct subsets of dopaminergic neurons that
  innervate the mushroom bodies in reward learning 
 and the control of motivated fly behaviour. Theref
 ore\, the positive reinforcement system of flies i
 s more similar to that of mammals than previously 
 envisaged.\n	One might interpret the relative ease
  of altering behaviour to indicate that everything
  is simple in the fly brain. However\, complexity 
 arises in unexpected ways. Cell-type specific gene
  expression profiling revealed transposable elemen
 t expression in long-term memory relevant neurons
 ofthemushroom body. Importantly\, brain-specific
  transposable element excision and insertion is he
 terogeneous within and between fly brains. Since n
 eural expression and retrotransposition of LINE-1 
 transposable elements has been observed in mammals
 \, it appears that genomic heterogeneity is a cons
 erved feature of the brain. We propose that it may
  prove beneficial to specific cell-types and neura
 l processes and could plausibly contribute to beha
 vioural individuality.\n
LOCATION:Part II room\,  Department of Genetics
CONTACT:Alison Read
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