BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:Cambridge Immunology Network Seminar Series
SUMMARY:&quot\;The impact of protease-regulated antigen pr
 ocessing and presentation&quot\; - Dr Timo Burster
 \, University of Ulm. Hosted by Dr Robert Busch
DTSTART;TZID=Europe/London:20120320T130000
DTEND;TZID=Europe/London:20120320T140000
UID:TALK37068AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/37068
DESCRIPTION:Three lines of inquiry will be presented. The firs
 t part of this talk will focus on the role of the 
 serine protease\, cathepsin G\, in processing of a
 ntigens for presentation to CD4+ T cells by MHC cl
 ass II molecules.  A novel affinity probe was used
  to demonstrate that cathepsin G enzymatic activit
 y is elevated in antigen-presenting cells from pat
 ients with type 1 diabetes.  This enzyme was shown
  to play a major role in the processing of proinsu
 lin\, an important diabetes autoantigen\, into fra
 gments recognised by patients' CD4+ T cells.  In a
  second line of investigation\, cathepsin G cleave
 d detergent-solubilised and recombinant soluble\, 
 but not membrane-bound MHC class II molecules\, ra
 ising the possibility that this enzyme may initiat
 e the disposal of class II molecules dislocated fr
 om the plasma membrane.  Finally\, Epstein-Barr vi
 rus was shown to evade immune recognition by CD4+ 
 T cells in part by modulating the level of catheps
 in D\, an aspartyl protease.\n\nDr Burster studied
  biology at the Universities of Freiburg and Tuebi
 ngen\, obtaining his PhD in Immunology in 2003.  F
 ollowing postdoctoral research at Stanford Univers
 ity (2003-6)\, he became a Group Leader at the Dep
 t of Internal Medicine at the University of Ulm(20
 06-11).  He obtained his university teaching quali
 fication (Habilitation) in Experimental Medicine i
 n 2010 and currently holds an honorary faculty pos
 ition (Privatdozent) at the Ulm University.
LOCATION:Rheumatology Seminar Room\, Dept of Medicine\, Lev
 el 5\,
CONTACT:Catie Heathfield
END:VEVENT
END:VCALENDAR