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CATEGORIES:Plant Sciences Research Seminars
SUMMARY:The FRIGIDA complex-mediated FLC activation in win
 ter annuals of Arabidopsis thaliana - Kyuha Choi
DTSTART;TZID=Europe/London:20110318T130000
DTEND;TZID=Europe/London:20110318T133000
UID:TALK30173AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/30173
DESCRIPTION:The winter annuals of Arabidopsis thaliana  requir
 e  vernalization-mediated silencing of the strong 
 flowering repressor FLOWERING LOCUS C (FLC) for fl
 oral promotion competence. FRIGIDA (FRI) encoding 
 a proline-rich protein with two coiled-coil domain
 s increases transcript level of FLC\, but the mole
 cular mechanism remains elusive. The natural mutat
 ions of FRI cause an early flowering with reduced 
 FLC expression in most of rapid life cycle ecotype
 s including Col-0. Forward genetic approaches usin
 g the winter annuals have identified additional ea
 rly flowering frl1\, fes1\, suf4 and flx\, similar
  to fri as mutants of FLC-specific activators. We 
 showed that FRI acts as a scaffold protein interac
 ting with FRL1\, FES1\, SUF4\, and FLX to form a t
 ranscription activator complex (FRI-C). Each compo
 nent of FRI-C has a specialized function. SUF4\, a
  C2H2 type zinc finger protein binds to a cis-elem
 ent of the FLC promoter\, FLX and FES1 have transc
 riptional activation potential\, and FRL1 and FES1
  stabilize the complex. FRI-C recruits a general t
 ranscription factor\, a TAF14 homolog\, and chroma
 tin modification factors\, the SWR1 complex and SE
 T2 homolog. Complex formation was confirmed by the
  immunoprecipitation of FRI-associated proteins fo
 llowed by mass spectrometric analysis. Our results
  provide insight into how a specific transcription
  activator recruits chromatin modifiers to regulat
 e a key flowering gene. 
LOCATION:Department of Plant Sciences\, Large Lecture Theat
 re
CONTACT:
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